Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 10/20 | 0.35 |
| ▸ | PPARG | P37231 | 8/20 | 0.35 |
| ▸ | PPARA | Q07869 | 8/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637199 | 0.79 | LTB4R (0.42) | PPARDPPARGPPARAMAPTLMNA | |
| SCHEMBL13637357 | 0.75 | LTB4R (0.39) | PPARDPPARGPPARA | |
| SCHEMBL13442143 | 0.74 | PPARG (0.38) | PPARDPPARGPPARA | |
| SCHEMBL13441643 | 0.73 | FFAR1 (0.39) | PPARDPPARGPPARAMEN1KMT2A | |
| SCHEMBL13637285 | 0.69 | PLA2G4B (0.38) | PPARDPPARGLMNAL3MBTL1MEN1 | |
| SCHEMBL13637162 | 0.65 | LTB4R (0.40) | PPARDPPARGPPARALMNA | |
| SCHEMBL9813446 | 0.65 | ALDH1A1 (0.50) | LMNAHPGDL3MBTL1RAB9AMEN1 | |
| SCHEMBL6933186 | 0.64 | PPARG (0.48) | PPARDPPARGPPARA | |
| SCHEMBL13441623 | 0.64 | LTB4R (0.46) | PPARDPPARGPPARAMAPTLMNA | |
| SCHEMBL13441399 | 0.62 | HDAC1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |