Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP10 | P09238 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581379 | 0.85 | FFAR1 (0.42) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL13637284 | 0.78 | FFAR1 (0.39) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL13407854 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL13637287 | 0.77 | ALDH1A1 (0.39) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL13442138 | 0.75 | PPARD (0.36) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL13442153 | 0.75 | KDM4E (0.36) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL3586378 | 0.72 | PPARG (0.40) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL3589424 | 0.70 | KDM4E (0.42) | KDM4EALDH1A1HPGDMAPTHDAC1 | |
| SCHEMBL13637161 | 0.68 | PPARD (0.42) | KDM4EALDH1A1HPGDMAPTHDAC1 | |
| SCHEMBL3587335 | 0.68 | KDM4E (0.46) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |