Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637284 | 0.97 | FFAR1 (0.39) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL3581379 | 0.86 | FFAR1 (0.42) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL13637283 | 0.82 | KDM4E (0.41) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL13407854 | 0.78 | KDM4E (0.46) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL13637288 | 0.77 | KDM4E (0.44) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL13637290 | 0.76 | ALDH1A1 (0.40) | ALDH1A1MAPTFFAR1HDAC1 | |
| SCHEMBL3589424 | 0.74 | KDM4E (0.42) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL13442138 | 0.74 | PPARD (0.36) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL13442153 | 0.74 | KDM4E (0.36) | ALDH1A1MAPTFFAR1KDM4EHPGD | |
| SCHEMBL3587335 | 0.69 | KDM4E (0.46) | ALDH1A1MAPTFFAR1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |