Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RPA1 | P27694 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637630 | 0.89 | PTGS2 (0.46) | MEN1KMT2ARPA1FABP3FABP4 | |
| SCHEMBL13212812 | 0.89 | MEN1 (0.43) | MEN1KMT2ARPA1PTGS2PTGS1 | |
| SCHEMBL13213071 | 0.89 | MEN1 (0.43) | MEN1KMT2ARPA1KDRPTGS2 | |
| SCHEMBL13213106 | 0.89 | CA9 (0.44) | MEN1KMT2ARPA1PTGS2RAB9A | |
| SCHEMBL13212894 | 0.88 | BCL2 (0.43) | MEN1KMT2ARPA1FABP3FABP4 | |
| SCHEMBL13213178 | 0.88 | ERN1 (0.42) | MEN1KMT2APTGS2PTGS1NPC1 | |
| SCHEMBL13213086 | 0.88 | ERN1 (0.40) | MEN1KMT2AKDRPTGS2NPC1 | |
| SCHEMBL13212839 | 0.88 | MDM2 (0.51) | MEN1KMT2ARPA1FABP3FABP4 | |
| SCHEMBL13212924 | 0.87 | MDM2 (0.42) | MEN1KMT2ARPA1FABP3FABP4 | |
| SCHEMBL13637333 | 0.86 | PTGS2 (0.40) | MEN1KMT2APTGS2PTGS1OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622471-B2 | Pyrazole derivatives having a pyridazine and pyridine functionality | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-11-24 | — | — | US | disclosed |