SCHEMBL1363735

SCHEMBL1363735

CCOC(=O)C(C(=O)CC)C(=O)OCC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOAT1 P35610 1/20 0.48
ALDH1A1 P00352 3/20 0.46
LMNA P02545 1/20 0.43
HSD17B10 Q99714 1/20 0.43
ALOX15 P16050 1/20 0.42
MGAM O43451 1/20 0.42
GAA P10253 1/20 0.42
SI P14410 1/20 0.42
MGAM2 Q2M2H8 1/20 0.42
TRPA1 O75762 1/20 0.39
PIN1 Q13526 1/20 0.35
AURKA O14965 1/20 0.35
NTRK1 P04629 1/20 0.35
HCAR2 Q8TDS4 1/20 0.34
MAPT P10636 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
KMT2A Q03164 1/20 0.34
CAD P27708 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3303175 0.88 ALDH1A1 (0.44) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL8228608 0.88 SOAT1 (0.42) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL425250 0.83 ALDH1A1 (0.56) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL3086153 0.80 ALDH1A1 (0.53) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL27955574 0.80 ALDH1A1 (0.46) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL9389312 0.80 ALDH1A1 (0.42) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL11194919 0.79 SOAT1 (0.48) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL8750495 0.79 SMN1; SMN2 (0.40) SOAT1ALDH1A1LMNAHSD17B10MGAM
SCHEMBL27821729 0.78 ALDH1A1 (0.40) SOAT1ALDH1A1LMNAHSD17B10ALOX15
SCHEMBL1148993 0.77 SOAT1 (0.46) SOAT1ALDH1A1LMNAHSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0367132-B1 Light-sensitive composition BASF AG (DE) 1997-04-02 EP claimed
US-5034305-A Mixtures for photoresists of water insolublr binders soluble in alkaline mixtures, compound forming a strong acid and solubility inhibitors BASF AKTIENGESELLSCHAFT (DE) 1991-07-23 US claimed
EP-0367132-A2 Light-sensitive composition BASF Aktiengesellschaft (DE) 1990-05-09 EP claimed
EP-2487177-A1 PYRAZOLOXAZOLE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2012-08-15 EP disclosed
US-8084449-B2 Dual pharmacophores—PDE4-muscarinic antagonistics GLAXO GROUP LIMITED (GB) 2011-12-27 US disclosed
US-8084449-B2 Dual pharmacophores—PDE4-muscarinic antagonistics GLAXO GROUP LIMITED (GB) 2011-12-27 US disclosed
US-8084449-B2 Dual pharmacophores—PDE4-muscarinic antagonistics GLAXO GROUP LIMITED (GB) 2011-12-27 US disclosed
US-8071588-B2 Dual pharmacophores—PDE4-muscarinic antagonistics GLAXO GROUP LIMITED (GB) 2011-12-06 US disclosed
US-8071588-B2 Dual pharmacophores—PDE4-muscarinic antagonistics GLAXO GROUP LIMITED (GB) 2011-12-06 US disclosed
US-8071588-B2 Dual pharmacophores—PDE4-muscarinic antagonistics GLAXO GROUP LIMITED (GB) 2011-12-06 US disclosed
US-8067408-B2 Dual pharmacophores—PDE4-muscarinic antagonistics GLAXO GROUP LIMITED (GB) 2011-11-29 US disclosed
WO-2007036734-A1 PYRAZOLO[3,4-B]PYRIDINE COMPOUND, AND ITS USE AS A PDE4 INHIBITOR GLAXO GROUP LIMITED (GB) 2007-04-05 WO disclosed
CN-1626496-A Method for preparing acyclic beta keto ester SHANGHAI INST OF CHEMICAL REAG (CN) 2005-06-15 CN disclosed
CN-1626498-A Method for preparing propionyl ethyl acetate SHANGHAI INST OF CHEMICAL REAG (CN) 2005-06-15 CN disclosed
EP-0367132-B1 Light-sensitive composition BASF AG (DE) 1997-04-02 EP disclosed
US-5464741-A Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays HENWELL, INC. (US) 1995-11-07 US disclosed
US-5034305-A Mixtures for photoresists of water insolublr binders soluble in alkaline mixtures, compound forming a strong acid and solubility inhibitors BASF AKTIENGESELLSCHAFT (DE) 1991-07-23 US disclosed
EP-0367132-A2 Light-sensitive composition BASF Aktiengesellschaft (DE) 1990-05-09 EP disclosed
EP-0101699-A1 UTILIZATION OF 2-(1-OXO-ALKYL)-5-PHENYL-2,4-PENTADIENE ACID ESTERS AS LIGHT FILTER SUBSTANCES Dragoco Gerberding & Co. GmbH (DE) 1984-03-07 EP disclosed
WO-1983002941-A1 UTILIZATION OF 2-(1-OXO-ALKYL)-5-PHENYL-2,4-PENTADIENE ACID ESTERS AS LIGHT FILTER SUBSTANCES BRUNKE, ERNST-JOACHIM 1983-09-01 WO disclosed