Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 17/20 | 0.65 |
| ▸ | IL1B | P01584 | 5/20 | 0.61 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12450483 | 0.94 | CASP1 (0.57) | CASP1IL1BMMEACE | |
| SCHEMBL12450482 | 0.94 | CASP1 (0.57) | CASP1IL1BMMEACE | |
| SCHEMBL12914464 | 0.94 | CASP1 (0.57) | CASP1IL1BMMEACE | |
| SCHEMBL647833 | 0.93 | CASP1 (0.77) | CASP1IL1BMMEACE | |
| SCHEMBL1078310 | 0.93 | CASP1 (0.77) | CASP1IL1BMMEACE | |
| SCHEMBL7250088 | 0.93 | CASP1 (0.77) | CASP1IL1BMMEACE | |
| SCHEMBL1078312 | 0.93 | CASP1 (0.77) | CASP1IL1BMMEACE | |
| SCHEMBL644613 | 0.88 | CASP1 (0.60) | CASP1IL1BMMEACE | |
| SCHEMBL7741379 | 0.88 | CASP1 (0.60) | CASP1IL1BMMEACE | |
| SCHEMBL10200742 | 0.88 | CASP1 (0.65) | CASP1IL1BMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2123665-A2 | Inhibitors of interleukin-1Beta converting enzyme | Vertex Pharmaceuticals Incorporated (US) | 2009-11-25 | — | — | EP | disclosed |