Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 15/20 | 0.60 |
| ▸ | IL1B | P01584 | 5/20 | 0.56 |
| ▸ | ACE | P12821 | 3/20 | 0.50 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644613 | 1.00 | CASP1 (0.60) | CASP1IL1BACEMME | |
| SCHEMBL12450884 | 0.97 | CASP1 (0.59) | CASP1IL1BACEMME | |
| SCHEMBL12450488 | 0.93 | CASP1 (0.53) | CASP1IL1BACEMME | |
| SCHEMBL12450485 | 0.91 | CASP1 (0.52) | CASP1IL1BACEMME | |
| SCHEMBL1078310 | 0.89 | CASP1 (0.77) | CASP1IL1BACEMME | |
| SCHEMBL647833 | 0.89 | CASP1 (0.77) | CASP1IL1BACEMME | |
| SCHEMBL1078312 | 0.89 | CASP1 (0.77) | CASP1IL1BACEMME | |
| SCHEMBL7250088 | 0.89 | CASP1 (0.77) | CASP1IL1BACEMME | |
| SCHEMBL13637686 | 0.88 | CASP1 (0.65) | CASP1IL1BACEMME | |
| SCHEMBL10200742 | 0.88 | CASP1 (0.65) | CASP1IL1BACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423840-B1 | FORMING N-ACYLAMINO COMPOUND | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-23 | — | — | US | disclosed |
| US-6420522-B1 | ENZYME INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-16 | — | — | US | disclosed |
| US-5874424-A | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-02-23 | — | — | US | disclosed |
| US-5847135-A | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1998-12-08 | — | — | US | disclosed |
| US-5716929-A | THERAPY FOR INFLAMMATION, AUTOIMMUNE DISEASES | VERTEX PHARMACEUTICALS, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5656627-A | USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE AND NEURODEGENERATIVE DISEASES | VERTEX PHARMACEUTICALS, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0784628-A1 | INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | Vertex Pharmaceuticals Incorporated (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1995035308-A1 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-12-28 | — | — | WO | disclosed |