Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628744 | 0.90 | MAPT (0.62) | SGK1LMNAMAPTGAATHRB | |
| SCHEMBL13628702 | 0.84 | SGK1 (0.63) | SGK1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL13628713 | 0.83 | SGK1 (0.64) | SGK1LMNAMAPTGAATHRB | |
| SCHEMBL13628735 | 0.82 | LMNA (0.76) | SGK1LMNAMAPTGAATHRB | |
| SCHEMBL13628763 | 0.82 | SGK1 (0.63) | SGK1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL13628758 | 0.81 | SGK1 (0.59) | SGK1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL13628738 | 0.81 | SGK1 (0.65) | SGK1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL13628743 | 0.81 | SGK1 (0.61) | SGK1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL13628722 | 0.79 | SGK1 (0.59) | SGK1LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL4559373 | 0.79 | ALDH1A1 (0.68) | SGK1LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619115-B2 | Ortho-substituted N'-benzylidene-(3-hydroxyphenyl)acethydrazides | MERCK PATENT GMBH (DE) | 2009-11-17 | — | — | US | disclosed |