Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.49 |
| ▸ | PLG | P00747 | 3/20 | 0.49 |
| ▸ | PLAU | P00749 | 3/20 | 0.49 |
| ▸ | PLAT | P00750 | 3/20 | 0.49 |
| ▸ | F10 | P00742 | 3/20 | 0.49 |
| ▸ | KLK8 | O60259 | 2/20 | 0.49 |
| ▸ | KLK4 | Q9Y5K2 | 2/20 | 0.49 |
| ▸ | ANPEP | P15144 | 2/20 | 0.48 |
| ▸ | LAP3 | P28838 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | KLK2 | P20151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363819 | 0.87 | F2 (0.56) | F2PLGPLAUPLATF10 | |
| Hydrochloric Acid SCHEMBL7387182 | 0.86 | F2 (0.55) | F2PLGPLAUPLATF10 | |
| Hydrochloric Acid SCHEMBL7422244 | 0.86 | F2 (0.55) | F2PLGPLAUPLATF10 | |
| SCHEMBL17125809 | 0.82 | ANPEP (0.45) | F2PLGPLAUPLATF10 | |
| SCHEMBL1443965 | 0.76 | CPN1 (0.45) | F2PLAUF10F12F7 | |
| Hydrochloric Acid SCHEMBL7390431 | 0.75 | PRSS1 (0.45) | F2PLAUF10F12F7 | |
| Hydrochloric Acid SCHEMBL7386657 | 0.75 | PRSS1 (0.45) | F2PLAUF10F12F7 | |
| SCHEMBL17008884 | 0.74 | PARP10 (0.51) | F2PLGPLAUPLATF10 | |
| SCHEMBL1364942 | 0.73 | PLAU (0.83) | F2PLGPLAUPLATF10 | |
| SCHEMBL6842194 | 0.73 | PLAU (0.72) | F2PLGPLAUPLATF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110287031-A1 | Covalently reactive transition state analogs and methods of use thereof | PAUL, SUDHIR, DR. | 2011-11-24 | — | — | US | disclosed |
| US-7524663-B2 | Covalently reactive transition state analogs and methods of use thereof | PAUL, SUDHIR, DR. | 2009-04-28 | — | — | US | disclosed |
| EP-1373307-A4 | COVALENTLY REACTIVE TRANSITION STATE ANALOGS AND METHODS OF USE THEREOF | UNIV TEXAS (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050142649-A1 | Covalently reactive transition state analogs and methods of use thereof | PAUL, SUDHIR, DR. | 2005-06-30 | — | — | US | disclosed |
| US-6855804-B2 | Covalently reactive transition state analogs and methods of use thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1373307-A2 | COVALENTLY REACTIVE TRANSITION STATE ANALOGS AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20030078203-A1 | Covalently reactive transition state analogs and methods of use thereof | PAUL, SUDHIR, DR. | 2003-04-24 | — | — | US | disclosed |
| WO-2002079223-A9 | COVALENTLY REACTIVE TRANSITION STATE ANALOGS AND METHODS OF USE THEREOF | UNIV TEXAS (US) | 2003-01-09 | — | — | WO | disclosed |
| WO-2002079223-A2 | COVALENTLY REACTIVE TRANSITION STATE ANALOGS AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050142649-A1 | Covalently reactive transition state analogs and methods of use thereof | SPR, FCGR3B, CD2 | F2 1565/4885PLG 470/4885PLAU 1537/4885 |
| US-20110287031-A1 | Covalently reactive transition state analogs and methods of use thereof | SPR, FCGR3B, CD2 | F2 1565/4885PLG 470/4885PLAU 1537/4885 |
| US-20030078203-A1 | Covalently reactive transition state analogs and methods of use thereof | SPR, FCGR3B, CD2 | F2 1565/4885PLG 470/4885PLAU 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.