Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 17/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14612876 | 0.91 | IKBKB (0.45) | IKBKBMAPK8MAPK10CHUKMAPK9 | |
| SCHEMBL14612807 | 0.86 | IKBKB (0.44) | IKBKBMAPK8MAPK10MAPK9CDK4 | |
| SCHEMBL3471961 | 0.86 | MEN1 (0.53) | IKBKBMAPK8MAPK10CHUKMAPK9 | |
| SCHEMBL13638533 | 0.85 | IKBKB (0.43) | IKBKBMAPK8MAPK10MAPK9CDK4 | |
| SCHEMBL13638440 | 0.85 | IKBKB (0.43) | IKBKBMAPK8MAPK10MAPK9CDK4 | |
| SCHEMBL13638678 | 0.84 | IKBKB (0.42) | IKBKBMAPK8MAPK14CDK4CDK2 | |
| SCHEMBL14612854 | 0.83 | IKBKB (0.42) | IKBKBMAPK8MAPK10MAPK9CDK4 | |
| SCHEMBL13638436 | 0.83 | IKBKB (0.42) | IKBKBMAPK8MAPK10CHUKMAPK9 | |
| SCHEMBL13638562 | 0.83 | IKBKB (0.39) | IKBKBMAPK8MAPK10CHUKMAPK9 | |
| SCHEMBL13638679 | 0.82 | IKBKB (0.41) | IKBKBMAPK8MAPK10CHUKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615562-B2 | Such as 2-methyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butan-2-ol; tumor necrosis factor inhibitors; immunosuppressants; antiinflammatory agents | NOVARTIS AG (CH) | 2009-11-10 | — | — | US | disclosed |