Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 14/20 | 0.45 |
| ▸ | DKK1 | O94907 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNH | P51946 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638478 | 0.91 | IKBKB (0.48) | IKBKBCDK2MAPK8CHUKMAPK10 | |
| SCHEMBL13638518 | 0.88 | IKBKB (0.38) | IKBKBDKK1GSK3BCCNT1CDK1 | |
| SCHEMBL13638562 | 0.87 | IKBKB (0.39) | IKBKBDKK1GSK3BCCNT1CDK1 | |
| SCHEMBL3470470 | 0.87 | IKBKB (0.49) | IKBKBDKK1GSK3BCCNT1CDK1 | |
| SCHEMBL13638302 | 0.86 | IKBKB (0.46) | IKBKBCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL14612849 | 0.86 | IKBKB (0.35) | IKBKBCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL13638286 | 0.86 | ROCK2 (0.35) | IKBKBCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL14612804 | 0.85 | MKNK1 (0.39) | IKBKBGSK3BCHUK | |
| SCHEMBL13638514 | 0.84 | IKBKB (0.33) | IKBKBCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL13638671 | 0.83 | HDAC8 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043048-A1 | 2-Aminopyrimidine derivatives and their medical use | NOVARTIS AG (CH) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043048-A1 | 2-Aminopyrimidine derivatives and their medical use | TPMT, IKBKB, CHUK | IKBKB 2/4885DKK1 3274/4885GSK3B 906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.