Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920090 | 0.91 | P2RY12 (0.48) | RAB9APPARGRXFP1NR2E3NCOR2 | |
| SCHEMBL9922338 | 0.86 | P2RY12 (0.39) | PPARGP2RY12MAPTCA12CA9 | |
| SCHEMBL14228643 | 0.84 | PPARG (0.41) | RAB9APPARGRXFP1NR2E3NCOR2 | |
| SCHEMBL14228568 | 0.83 | P2RY12 (0.39) | PPARGP2RY12CA12CA9CA1 | |
| SCHEMBL14113531 | 0.83 | P2RY12 (0.39) | RAB9APPARGRXFP1NR2E3NCOR2 | |
| SCHEMBL4687896 | 0.82 | P2RY12 (0.45) | PPARGRXFP1P2RY12MAPTCA12 | |
| SCHEMBL9922795 | 0.82 | P2RY12 (0.38) | PPARGP2RY12CA12CA9CA1 | |
| SCHEMBL14357209 | 0.82 | P2RY12 (0.55) | PPARGP2RY12MAPTALDH1A1CA12 | |
| SCHEMBL14228331 | 0.81 | P2RY12 (0.36) | RAB9APPARGP2RY12SMN1; SMN2CA12 | |
| SCHEMBL12161818 | 0.81 | P2RY12 (0.50) | RAB9APPARGRXFP1NR2E3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |