Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 14/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922708 | 0.92 | P2RY12 (0.47) | PPARGRAB9ARXFP1NR2E3NCOR2 | |
| SCHEMBL12177640 | 0.86 | ESR1 (0.39) | PPARGRAB9AESR1ESR2P2RY12 | |
| SCHEMBL13638705 | 0.86 | ATM (0.43) | ATM | |
| SCHEMBL13638369 | 0.85 | ESR1 (0.38) | PPARGRAB9AESR1ESR2P2RY12 | |
| SCHEMBL13638647 | 0.85 | P2RY12 (0.39) | PPARGRAB9AESR1ESR2P2RY12 | |
| SCHEMBL13638511 | 0.84 | P2RY12 (0.45) | PPARGRAB9ARXFP1NR2E3NCOR2 | |
| SCHEMBL13638502 | 0.84 | RAB9A (0.42) | PPARGRAB9ARXFP1NR2E3NCOR2 | |
| SCHEMBL13638370 | 0.84 | P2RY12 (0.38) | PPARGRAB9AESR1ESR2P2RY12 | |
| SCHEMBL13638371 | 0.83 | P2RY12 (0.38) | RAB9AESR1ESR2P2RY12GAA | |
| SCHEMBL13638645 | 0.83 | P2RY12 (0.43) | PPARGRAB9AESR1ESR2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |