Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 6/20 | 0.33 |
| ▸ | CA9 | Q16790 | 6/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922796 | 0.90 | P2RY12 (0.44) | P2RY12NPC1RAB9ASMN1; SMN2FBP1 | |
| SCHEMBL12177672 | 0.88 | P2RY12 (0.37) | P2RY12NPC1RAB9ASMN1; SMN2PPARG | |
| SCHEMBL9922778 | 0.88 | P2RY12 (0.37) | P2RY12NPC1RAB9ASMN1; SMN2PPARG | |
| SCHEMBL12161548 | 0.86 | P2RY12 (0.36) | P2RY12NPC1RAB9ASMN1; SMN2CA12 | |
| SCHEMBL13638502 | 0.81 | RAB9A (0.42) | P2RY12RAB9ASMN1; SMN2PPARGCA12 | |
| SCHEMBL9922312 | 0.81 | FBP1 (0.41) | P2RY12NPC1RAB9ASMN1; SMN2CA12 | |
| SCHEMBL14113531 | 0.81 | P2RY12 (0.39) | P2RY12RAB9APPARGCA12CA9 | |
| SCHEMBL9922874 | 0.80 | P2RY12 (0.34) | P2RY12NPC1RAB9ASMN1; SMN2CA12 | |
| SCHEMBL9922816 | 0.80 | P2RY12 (0.40) | P2RY12NPC1RAB9ASMN1; SMN2CA12 | |
| SCHEMBL4687896 | 0.80 | P2RY12 (0.45) | P2RY12PPARGCA12CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |