Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476836 | 0.88 | KCNH2 (0.42) | EIF2AK2KCNH2FGFR1FGFR4CHRNA7 | |
| SCHEMBL13638316 | 0.87 | KCNH2 (0.44) | KCNH2MERTK | |
| SCHEMBL13638581 | 0.86 | EIF2AK2 (0.40) | EIF2AK2KCNH2FGFR1FGFR4 | |
| SCHEMBL13638475 | 0.84 | ADRB2 (0.35) | — | |
| SCHEMBL13638524 | 0.76 | KCNH2 (0.33) | EIF2AK2KCNH2 | |
| SCHEMBL14612852 | 0.76 | KCNH2 (0.39) | KCNH2MERTK | |
| SCHEMBL13638308 | 0.76 | KCNH2 (0.34) | EIF2AK2KCNH2SMN1; SMN2 | |
| SCHEMBL3476962 | 0.74 | KCNH2 (0.58) | KCNH2MERTK | |
| SCHEMBL13638505 | 0.74 | JUN (0.31) | — | |
| SCHEMBL13638661 | 0.73 | RPS6KB2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615562-B2 | Such as 2-methyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butan-2-ol; tumor necrosis factor inhibitors; immunosuppressants; antiinflammatory agents | NOVARTIS AG (CH) | 2009-11-10 | — | — | US | disclosed |