Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTR3A | P46098 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638520 | 0.88 | P2RY12 (0.47) | P2RY12TP53RXFP1SMN1; SMN2MAPT | |
| SCHEMBL13638528 | 0.88 | P2RY12 (0.46) | P2RY12TP53RXFP1HTR3AMAPT | |
| SCHEMBL6017209 | 0.85 | P2RY12 (0.54) | P2RY12TP53RXFP1SMN1; SMN2HTR3A | |
| SCHEMBL9922413 | 0.78 | P2RY12 (0.59) | P2RY12TP53RXFP1SMN1; SMN2HTR3A | |
| SCHEMBL13638711 | 0.78 | P2RY12 (0.63) | P2RY12SMN1; SMN2MAPTAKR1C3AKR1C2 | |
| SCHEMBL9922412 | 0.77 | P2RY12 (0.54) | P2RY12TP53RXFP1SMN1; SMN2MAPT | |
| SCHEMBL9922411 | 0.77 | P2RY12 (0.53) | P2RY12TP53RXFP1SMN1; SMN2MAPT | |
| SCHEMBL4412345 | 0.76 | P2RY12 (0.49) | P2RY12TP53RXFP1SMN1; SMN2HTR3A | |
| SCHEMBL4412669 | 0.75 | P2RY12 (0.70) | P2RY12TP53RXFP1SMN1; SMN2MAPT | |
| SCHEMBL13635177 | 0.74 | P2RY12 (0.57) | P2RY12TP53RXFP1SMN1; SMN2HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |