Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922944 | 0.92 | P2RY12 (0.42) | P2RY12MAPTTP53GCK | |
| SCHEMBL9923187 | 0.90 | P2RY12 (0.37) | P2RY12METMAPK14MEN1KMT2A | |
| SCHEMBL12177093 | 0.89 | P2RY12 (0.37) | P2RY12METMAPK14MEN1KMT2A | |
| SCHEMBL14113771 | 0.89 | ESR1 (0.36) | P2RY12METMAPK14MAPTTP53 | |
| SCHEMBL14228581 | 0.88 | P2RY12 (0.42) | P2RY12METMAPK14MEN1KMT2A | |
| SCHEMBL12177096 | 0.87 | ATM (0.41) | P2RY12MEN1KMT2A | |
| SCHEMBL12177092 | 0.86 | TERT (0.38) | P2RY12METMAPK14MAPTMEN1 | |
| SCHEMBL14113603 | 0.85 | MET (0.39) | METKITKDR | |
| SCHEMBL14228477 | 0.85 | MET (0.39) | P2RY12METMAPK14 | |
| SCHEMBL9923206 | 0.84 | P2RY12 (0.39) | P2RY12MAPTTP53GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |