Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 12/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | CDK11B | P21127 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.46 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3471459 | 0.87 | MAPK8 (0.49) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL13638441 | 0.85 | MAPK8 (0.58) | MAPK8MAPK9MAPK10MKNK1 | |
| SCHEMBL13638681 | 0.84 | MAPK8 (0.48) | MAPK8MAPK9MAPK10 | |
| SCHEMBL13638593 | 0.82 | ROCK1 (0.49) | MAPK8MAPK9MAPK10EIF2AK2MKNK1 | |
| SCHEMBL14193374 | 0.80 | MAPK8 (0.62) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL5093822 | 0.78 | MAPK8 (0.71) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL3814633 | 0.78 | MAPK8 (0.71) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL13638589 | 0.77 | MAPK8 (0.42) | MAPK8MAPK9MAPK10MKNK1 | |
| SCHEMBL13638311 | 0.76 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MKNK1 | |
| SCHEMBL6039567 | 0.74 | MAPK8 (0.59) | MAPK8MAPK9MAPK10CITDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615562-B2 | Such as 2-methyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butan-2-ol; tumor necrosis factor inhibitors; immunosuppressants; antiinflammatory agents | NOVARTIS AG (CH) | 2009-11-10 | — | — | US | disclosed |