Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 10/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470784 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL13638593 | 0.85 | ROCK1 (0.49) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL13638543 | 0.85 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MKNK1 | |
| SCHEMBL13638681 | 0.82 | MAPK8 (0.48) | MAPK8MAPK9MAPK10 | |
| SCHEMBL13638589 | 0.80 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL13638311 | 0.80 | MAPK8 (0.47) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL13638678 | 0.76 | IKBKB (0.42) | MAPK8CDK2 | |
| SCHEMBL5094294 | 0.75 | MAPK8 (0.78) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL13638416 | 0.75 | IKBKB (0.35) | MAPK8MAPK9MAPK10CDK2 | |
| SCHEMBL13638545 | 0.74 | CCNB2 (0.48) | CDK2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615562-B2 | Such as 2-methyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butan-2-ol; tumor necrosis factor inhibitors; immunosuppressants; antiinflammatory agents | NOVARTIS AG (CH) | 2009-11-10 | — | — | US | disclosed |