Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14113598 | 0.83 | MAPK14 (0.31) | MAPK14 | |
| SCHEMBL9922706 | 0.82 | P2RY12 (0.47) | MAPK14KMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL13638535 | 0.81 | MAPK14 (0.36) | MAPK14KMT2AHSD17B10MAPTLMNA | |
| SCHEMBL13638648 | 0.75 | GLA (0.48) | KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL14113578 | 0.74 | ESR1 (0.37) | MAPK14SMN1; SMN2ATM | |
| SCHEMBL12177063 | 0.74 | P2RY12 (0.32) | KMT2AMEN1 | |
| SCHEMBL9922350 | 0.74 | P2RY12 (0.45) | MAPK14KMT2AMEN1HSD17B10MAPT | |
| SCHEMBL9922157 | 0.74 | P2RY12 (0.42) | MAPK14KMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL12177061 | 0.74 | KMT2A (0.36) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL14228476 | 0.73 | MAPT (0.39) | MAPK14KMT2AMEN1SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |