Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.38 |
| ▸ | PDE4A | P27815 | 10/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461386 | 0.82 | MELK (0.42) | KDM4EALDH1A1POLBMAPT | |
| SCHEMBL13711713 | 0.78 | CCNA2 (0.60) | CCNA2CDK2KDM4EALDH1A1LMNA | |
| SCHEMBL27695663 | 0.66 | MAPK10 (0.62) | ALDH1A1LMNANPC1MAPTHTT | |
| SCHEMBL10252621 | 0.63 | ALOX15 (0.42) | CCNA2CDK2KDM4EALDH1A1LMNA | |
| SCHEMBL27724966 | 0.60 | HCAR3 (0.40) | CCNA2CDK2KDM4EALDH1A1LMNA | |
| SCHEMBL12998885 | 0.60 | SYK (0.52) | CCNA2CDK2ALDH1A1LMNAPOLB | |
| SCHEMBL27725018 | 0.59 | HCAR3 (0.39) | CCNA2CDK2KDM4EALDH1A1LMNA | |
| SCHEMBL10425208 | 0.59 | SYK (0.51) | ALDH1A1LMNAPOLBNPC1MAPT | |
| SCHEMBL7392417 | 0.58 | TP53 (0.66) | KDM4EALDH1A1LMNANPC1MAPT | |
| SCHEMBL16075241 | 0.57 | MAPT (0.42) | EEF2KKDM4EALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286793-A1 | PDE4B INHIBITORS AND USES THEREFOR | PDE4B, PDE7B, PDE4A | BRAF 1936/4885PDE4A 3/4885PDE4B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.