Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 4/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922996 | 0.93 | P2RY12 (0.44) | P2RY12TP53FBP1MEN1LMNA | |
| SCHEMBL13638637 | 0.87 | P2RY12 (0.36) | P2RY12TP53FBP1CREBBPBRD4 | |
| SCHEMBL9922994 | 0.82 | P2RY12 (0.43) | P2RY12FBP1MEN1LMNAKMT2A | |
| SCHEMBL9922690 | 0.81 | P2RY12 (0.46) | P2RY12FBP1MEN1LMNAKMT2A | |
| SCHEMBL13638632 | 0.81 | P2RY12 (0.42) | P2RY12TP53CREBBPBRD4MEN1 | |
| SCHEMBL13638707 | 0.80 | P2RY12 (0.54) | P2RY12TP53FBP1CREBBPBRD4 | |
| SCHEMBL9920086 | 0.79 | P2RY12 (0.54) | P2RY12FBP1MEN1LMNAKMT2A | |
| SCHEMBL9923273 | 0.79 | P2RY12 (0.43) | P2RY12FBP1MEN1LMNAKMT2A | |
| SCHEMBL12177212 | 0.78 | P2RY12 (0.34) | P2RY12FBP1CREBBPBRD4MEN1 | |
| SCHEMBL13638634 | 0.78 | P2RY12 (0.34) | P2RY12FBP1CREBBPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |