Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KCNA1 | Q09470 | 4/20 | 0.35 |
| ▸ | KCNAB1 | Q14722 | 4/20 | 0.35 |
| ▸ | FBP1 | P09467 | 3/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922213 | 0.93 | CA12 (0.36) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL9922209 | 0.91 | CA12 (0.36) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL14228254 | 0.91 | FPR2 (0.36) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL9922214 | 0.90 | FBP1 (0.36) | CA12CA1CA2CA9FBP1 | |
| SCHEMBL12177301 | 0.90 | CA12 (0.33) | CA12CA1CA2CA9FBP1 | |
| SCHEMBL9922182 | 0.90 | CA12 (0.33) | CA12CA1CA2CA9FBP1 | |
| SCHEMBL12161605 | 0.90 | P2RY12 (0.32) | CA12CA1CA2CA9FBP1 | |
| SCHEMBL12161602 | 0.90 | KMT2A (0.41) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL9922210 | 0.89 | CA12 (0.41) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL9922211 | 0.89 | MAPT (0.35) | CA12CA1CA2CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |