Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.35 |
| ▸ | CA9 | Q16790 | 6/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13182875 | 0.91 | P2RY12 (0.36) | CA12CA9CA1CA2NLRP3 | |
| SCHEMBL12177517 | 0.91 | MEN1 (0.41) | CA12CA9CA1CA2NLRP3 | |
| SCHEMBL13182873 | 0.89 | P2RY12 (0.36) | CA12CA9CA1CA2NLRP3 | |
| SCHEMBL13182765 | 0.85 | CA12 (0.35) | CA12CA9CA1CA2NLRP3 | |
| SCHEMBL9923259 | 0.82 | P2RY12 (0.44) | CA12CA9CA1NLRP3P2RY12 | |
| SCHEMBL13638642 | 0.81 | P2RY12 (0.36) | CA12CA9CA1CA2NLRP3 | |
| SCHEMBL9923256 | 0.80 | P2RY12 (0.48) | NLRP3P2RY12MEN1KMT2AKDM4E | |
| SCHEMBL9922371 | 0.79 | P2RY12 (0.46) | NLRP3P2RY12MEN1KMT2ALMNA | |
| SCHEMBL12177418 | 0.76 | LMNA (0.41) | CA12CA9CA1CA2NLRP3 | |
| SCHEMBL9922637 | 0.75 | FBP1 (0.45) | CA12CA9CA1CA2P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |