Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 5/20 | 0.35 |
| ▸ | ESR1 | P03372 | 4/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10059604 | 0.86 | MAPT (0.37) | ESR2ESR1TDP2MEN1GAA | |
| SCHEMBL10079849 | 0.83 | ALOX15 (0.43) | ESR2ESR1TDP2MEN1GAA | |
| SCHEMBL12333101 | 0.82 | NPC1 (0.40) | MEN1KMT2APIK3CA | |
| SCHEMBL10059678 | 0.81 | PARP10 (0.43) | MEN1GAAKMT2AALDH1A1HTT | |
| SCHEMBL10079095 | 0.80 | ALOX15 (0.46) | ESR2ESR1MEN1GAAKMT2A | |
| SCHEMBL13639026 | 0.79 | HRH4 (0.49) | HRH4 | |
| SCHEMBL10079099 | 0.77 | SRC (0.44) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL10079694 | 0.76 | CA12 (0.52) | MEN1GAAKMT2AKDM4EMAPT | |
| SCHEMBL10059623 | 0.75 | ALKBH5 (0.50) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL10059614 | 0.75 | HPGD (0.47) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304413-B2 | Compounds and methods for treating inflammatory and fibrotic disorders | INTERMUNE, INC. (US) | 2012-11-06 | — | — | US | disclosed |