Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.30 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13636276 | 0.84 | MEN1 (0.34) | TRPV1ALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL13639105 | 0.84 | L3MBTL1 (0.38) | TRPV1ALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL13639032 | 0.81 | L3MBTL1 (0.36) | TRPV1ALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL13822036 | 0.76 | CYP1A1 (0.35) | TRPV1ALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL7989707 | 0.74 | ACHE (0.38) | ALDH1A1CYP1A1CYP1A2NFE2L2CYP1B1 | |
| SCHEMBL13636262 | 0.74 | MEN1 (0.36) | TRPV1ALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL13845921 | 0.73 | CYP1A1 (0.33) | ALDH1A1SMN1; SMN2CYP1A1CYP1A2NFE2L2 | |
| SCHEMBL13639103 | 0.73 | TACR1 (0.36) | ALDH1A1SMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL13636291 | 0.72 | HTT (0.37) | TRPV1ALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL13636257 | 0.72 | MEN1 (0.36) | TRPV1ALDH1A1SMN1; SMN2CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304385-B2 | Macrocyclic tetrazolyl hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-20090142299-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090142299-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS4, PRSS1, SPINT2 | TRPV1 2679/4885ALDH1A1 1028/4885SMN1; SMN2 3603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.