Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 2/20 | 0.34 |
| ▸ | ATP4B | P51164 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL930136 | 0.95 | MEN1 (0.36) | MEN1KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL930607 | 0.89 | L3MBTL1 (0.39) | MEN1KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL14344425 | 0.82 | GAA (0.42) | MEN1KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL13099831 | 0.81 | HSP90AA1 (0.35) | MEN1KMT2AL3MBTL1MAPTLMNA | |
| SCHEMBL977473 | 0.81 | MEN1 (0.35) | MEN1KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL14293305 | 0.80 | — | — | |
| SCHEMBL930886 | 0.79 | MEN1 (0.33) | MEN1KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL931450 | 0.78 | ESR1 (0.36) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL788553 | 0.78 | MEN1 (0.33) | MEN1KMT2AALDH1A1HPGDPOLB | |
| SCHEMBL2596705 | 0.78 | MEN1 (0.33) | MEN1KMT2AALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817295-B1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP (US) | 2012-11-07 | — | — | EP | disclosed |