Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.82 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4579844 | 0.93 | IL6 (0.90) | IL6HTR2CBACE1KMT2AMEN1 | |
| SCHEMBL4580952 | 0.91 | IL6 (0.86) | IL6HTR2CBACE1KMT2AMEN1 | |
| SCHEMBL4581788 | 0.90 | IL6 (1.00) | IL6HTR2CBACE1KMT2AMEN1 | |
| SCHEMBL4581342 | 0.90 | IL6 (0.84) | IL6HTR2CBACE1KMT2AMEN1 | |
| SCHEMBL4134613 | 0.90 | IL6 (0.84) | IL6HTR2CKMT2AMEN1ALDH1A1 | |
| SCHEMBL4135144 | 0.89 | IL6 (0.83) | IL6HTR2CBACE1KMT2AMEN1 | |
| SCHEMBL4126541 | 0.89 | IL6 (0.83) | IL6HTR2CALDH1A1KDM4E | |
| SCHEMBL4127299 | 0.89 | IL6 (0.82) | IL6HTR2CKMT2AMEN1KDM4E | |
| SCHEMBL4582039 | 0.89 | IL6 (0.82) | IL6HTR2CBACE1KMT2AMEN1 | |
| SCHEMBL4141804 | 0.88 | IL6 (0.81) | IL6HTR2CFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |