Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077372 | 0.80 | GABRA1 (0.66) | GABRA1GABRB1GAAHTTALDH1A1 | |
| SCHEMBL103818 | 0.75 | SMN1; SMN2 (0.55) | HTTALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL31003199 | 0.73 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2HSP90AA1ERN1 | |
| SCHEMBL23882806 | 0.73 | CYP3A4 (0.47) | HTTALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL8248223 | 0.72 | ALDH1A1 (0.52) | ALDH1A1HPGDSMN1; SMN2HSP90AA1ERN1 | |
| SCHEMBL12052087 | 0.72 | ALDH1A1 (0.52) | ALDH1A1HPGDSMN1; SMN2HSP90AA1ERN1 | |
| SCHEMBL24603706 | 0.71 | HSP90AA1 (0.69) | GABRA1GABRB1GAAALDH1A1HPGD | |
| SCHEMBL2417299 | 0.71 | TOP2A (0.46) | GABRA1GABRB1HPGDHSP90AA1HSP90AB1 | |
| SCHEMBL15459992 | 0.71 | HSP90AA1 (0.50) | GABRA1GABRB1GAAALDH1A1HPGD | |
| SCHEMBL10283437 | 0.71 | HPGD (0.50) | HTTALDH1A1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520290-A1 | Propofol analogs, process for their preparation, and methods of use | Abraxis BioScience, LLC (US) | 2012-11-07 | — | — | EP | disclosed |