Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 19/20 | 0.70 |
| ▸ | CDK2 | P24941 | 19/20 | 0.70 |
| ▸ | CCNE2 | O96020 | 17/20 | 0.70 |
| ▸ | CDK4 | P11802 | 11/20 | 0.59 |
| ▸ | CCND1 | P24385 | 10/20 | 0.59 |
| ▸ | CDK1 | P06493 | 9/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 8/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.59 |
| ▸ | CCNB3 | Q8WWL7 | 8/20 | 0.59 |
| ▸ | CCND2 | P30279 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666164 | 0.85 | CCNE1 (0.69) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL16731888 | 0.82 | CCNE1 (0.68) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL12466 | 0.82 | CCNE2 (0.58) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL1240028 | 0.78 | CCNE1 (0.46) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL9096131 | 0.78 | CCNE1 (0.61) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL16724112 | 0.78 | CCNE1 (0.44) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL2606483 | 0.76 | CDK2 (0.44) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL1263091 | 0.76 | GCK (0.45) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL998883 | 0.76 | CCNE1 (0.43) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL1000207 | 0.76 | CCNE1 (0.43) | CCNE1CDK2CCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723128-B1 | HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS | NOVO NORDISK AS (DK) | 2012-11-07 | — | — | EP | disclosed |