Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.68 |
| ▸ | CDK2 | P24941 | 20/20 | 0.68 |
| ▸ | CCNE2 | O96020 | 19/20 | 0.68 |
| ▸ | CDK4 | P11802 | 12/20 | 0.68 |
| ▸ | CCND1 | P24385 | 11/20 | 0.68 |
| ▸ | CDK1 | P06493 | 10/20 | 0.68 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.68 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.68 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.68 |
| ▸ | CCND2 | P30279 | 1/20 | 0.59 |
| ▸ | CCND3 | P30281 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666164 | 0.84 | CCNE1 (0.69) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL9096131 | 0.83 | CCNE1 (0.61) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL13639769 | 0.82 | CCNE1 (0.70) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL5216840 | 0.80 | CCNE1 (0.67) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL5214383 | 0.79 | CCNE1 (0.61) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL5216993 | 0.78 | CCNE1 (1.00) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL5213819 | 0.78 | CCNE2 (1.00) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4731497 | 0.77 | CDK2 (1.00) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL5215449 | 0.76 | CCNE1 (0.55) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL27479700 | 0.76 | CCNE1 (0.58) | CCNE1CDK2CCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587411-B1 | 1-(ALPHA-METHYLBENZYL)-5-(PIPERIDINOMETHYL)IMIDAZOLE DERIVATIVES AND USES THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME (US) | 2021-01-27 | — | — | EP | disclosed |
| US-10745377-B2 | Piperidine or piperazine linked imidazole and triazole derivatives and methods of use | MERCK SHARP & DOHME CORP. (US) | 2020-08-18 | — | — | US | disclosed |
| EP-3068390-B1 | PIPERAZINE-IMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME (US) | 2019-06-26 | — | — | EP | disclosed |
| US-20160297792-A1 | PIPERIDINE OR PIPERAZINE LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME CORP. (US) | 2016-10-13 | — | — | US | disclosed |
| US-20160297792-A1 | PIPERIDINE OR PIPERAZINE LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME CORP. (US) | 2016-10-13 | — | — | US | disclosed |
| WO-2015073310-A1 | PIPERIDINE OR PIPERAZINE LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME CORP. (US) | 2015-05-21 | — | — | WO | disclosed |
| WO-2015070367-A1 | PIPERIDINE OR PIPERAZINE LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME CORP. (US) | 2015-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745377-B2 | Piperidine or piperazine linked imidazole and triazole derivatives and methods of use | CYP3A5, CYP3A43, CYP3A4 | CCNE1 3099/4885CDK2 1022/4885CCNE2 3722/4885 |
| US-20160297792-A1 | PIPERIDINE OR PIPERAZINE LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | CYP3A5, CYP3A43, CYP3A7 | CCNE1 3242/4885CDK2 1456/4885CCNE2 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.