Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.98 |
| ▸ | HTR3A | P46098 | 6/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1376239 | 0.99 | HRH3 (1.00) | HRH3HTR3AKCNH2ADORA2AATM | |
| SCHEMBL1375082 | 0.99 | HRH3 (1.00) | HRH3HTR3AKCNH2ADORA2AATM | |
| SCHEMBL1375085 | 0.99 | HRH3 (1.00) | HRH3HTR3AKCNH2ADORA2AATM | |
| SCHEMBL1376743 | 0.84 | HRH3 (1.00) | HRH3HTR3AKCNH2 | |
| SCHEMBL1372936 | 0.84 | HRH3 (1.00) | HRH3HTR3AKCNH2 | |
| SCHEMBL1372932 | 0.84 | HRH3 (1.00) | HRH3HTR3AKCNH2 | |
| SCHEMBL14308933 | 0.80 | HTR3A (0.98) | HRH3HTR3AKCNH2 | |
| SCHEMBL10197092 | 0.79 | HTR3A (1.00) | HRH3HTR3AKCNH2 | |
| SCHEMBL10267647 | 0.78 | HRH3 (0.66) | HRH3HTR3AKCNH2KMT2A | |
| SCHEMBL13639811 | 0.76 | HRH3 (0.60) | HRH3HTR3AKCNH2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-B1 | PYRIDIZINONE DERIVATIVES | CEPHALON INC (US) | 2012-11-07 | — | — | EP | disclosed |