SCHEMBL13639811

SCHEMBL13639811

CCCC[C@@H](C)CCC(C)C[C@@H](C)COc1ccc(-c2cn[nH]c(=O)c2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.60
HTR3A P46098 2/20 0.47
KCNH2 Q12809 2/20 0.45
CYP2D6 P10635 4/20 0.39
CYP2C9 P11712 4/20 0.39
CYP2C19 P33261 4/20 0.39
CYP3A4 P08684 3/20 0.39
GPR84 Q9NQS5 1/20 0.38
CYP1A2 P05177 3/20 0.36
CYP19A1 P11511 3/20 0.36
XDH P47989 2/20 0.36
NPC1 O15118 1/20 0.35
TP53 P04637 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ALPL P05186 1/20 0.35
CYP11B1 P15538 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31020318 0.76 HTR3A (0.57) HRH3HTR3AKCNH2XDHNPC1
SCHEMBL13639810 0.76 HRH3 (0.98) HRH3HTR3AKCNH2CYP2D6CYP2C19
SCHEMBL1375082 0.75 HRH3 (1.00) HRH3HTR3AKCNH2CYP2D6CYP2C19
SCHEMBL1376239 0.75 HRH3 (1.00) HRH3HTR3AKCNH2CYP2D6CYP2C19
SCHEMBL1375085 0.75 HRH3 (1.00) HRH3HTR3AKCNH2CYP2D6CYP2C19
SCHEMBL1376653 0.71 HTR3A (0.65) HRH3HTR3AKCNH2CYP2D6CYP2C9
SCHEMBL1372936 0.70 HRH3 (1.00) HRH3HTR3AKCNH2
SCHEMBL1376743 0.70 HRH3 (1.00) HRH3HTR3AKCNH2
SCHEMBL20357815 0.70 CYP3A4 (0.47) CYP2D6CYP2C9CYP2C19CYP3A4CYP1A2
SCHEMBL27844315 0.70 HTR3A (0.52) HRH3HTR3AKCNH2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2069312-B1 PYRIDIZINONE DERIVATIVES CEPHALON INC (US) 2012-11-07 EP disclosed