Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 8/20 | 1.00 |
| ▸ | MAP3K9 | P80192 | 7/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.91 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.91 |
| ▸ | PRKCA | P17252 | 3/20 | 0.70 |
| ▸ | CDK4 | P11802 | 2/20 | 0.70 |
| ▸ | CCND1 | P24385 | 2/20 | 0.70 |
| ▸ | GLI1 | P08151 | 2/20 | 0.70 |
| ▸ | GLI2 | P10070 | 2/20 | 0.70 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.70 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.70 |
| ▸ | PRKCG | P05129 | 1/20 | 0.70 |
| ▸ | PRKCB | P05771 | 1/20 | 0.70 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.70 |
| ▸ | PRKACA | P17612 | 1/20 | 0.70 |
| ▸ | PRKACG | P22612 | 1/20 | 0.70 |
| ▸ | PRKACB | P22694 | 1/20 | 0.70 |
| ▸ | PRKCH | P24723 | 1/20 | 0.70 |
| ▸ | PRKCI | P41743 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13140090 | 0.95 | MAP3K11 (1.00) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| Staurosporinone SCHEMBL29374983 | 0.83 | MAP3K11 (1.00) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| Staurosporinone SCHEMBL29389399 | 0.83 | MAP3K11 (1.00) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| Staurosporinone SCHEMBL5440281 | 0.83 | MAP3K11 (1.00) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| SCHEMBL29506382 | 0.75 | MEN1 (0.69) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| SCHEMBL15138782 | 0.75 | MEN1 (0.69) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| SCHEMBL30887363 | 0.75 | MEN1 (0.69) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| SCHEMBL22011388 | 0.75 | MAP3K9 (0.67) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| SCHEMBL16867092 | 0.74 | MAP3K9 (0.65) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA | |
| SCHEMBL9270827 | 0.73 | MAP3K11 (0.78) | MAP3K11MAP3K9NTRK1MAP3K10PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350087-B1 | REGIOSELECTIVE REDUCTION OF FUSED PYRROLOCARBAZOLES-5,7-DIONES | CEPHALON FRANCE (FR) | 2012-11-07 | — | — | EP | disclosed |