Staurosporinone

Staurosporinone

SCHEMBL29389399

O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP3K11 Q16584 7/20 1.00
▸ MAP3K9 P80192 6/20 1.00
▸ PRKCA P17252 4/20 1.00
▸ PRKCQ Q04759 3/20 1.00
▸ PRKCD Q05655 3/20 1.00
▸ GLI1 P08151 2/20 1.00
▸ GLI2 P10070 2/20 1.00
▸ PRKD3 O94806 2/20 1.00
▸ PRKCG P05129 2/20 1.00
▸ PRKCB P05771 2/20 1.00
▸ PRKCH P24723 2/20 1.00
▸ PRKCI P41743 2/20 1.00
▸ PRKCE Q02156 2/20 1.00
▸ PRKCZ Q05513 2/20 1.00
▸ PRKD1 Q15139 2/20 1.00
▸ CDK4 P11802 1/20 1.00
▸ CTRB1 P17538 1/20 1.00
▸ PRKACA P17612 1/20 1.00
▸ PRKACG P22612 1/20 1.00
▸ PRKACB P22694 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Staurosporinone SCHEMBL5440281 1.00 MAP3K11 (1.00) MAP3K11MAP3K9PRKCAPRKCQPRKCD
Staurosporinone SCHEMBL29374983 1.00 MAP3K11 (1.00) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL9263371 0.88 MAP3K11 (0.78) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL9270827 0.88 MAP3K11 (0.78) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL9260091 0.85 ROCK2 (0.78) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL9263506 0.85 ROCK2 (0.78) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL13639843 0.83 MAP3K11 (1.00) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL13639845 0.83 MAP3K11 (1.00) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL13140090 0.83 MAP3K11 (1.00) MAP3K11MAP3K9PRKCAPRKCQPRKCD
SCHEMBL13431719 0.82 MAP3K11 (0.69) MAP3K11MAP3K9PRKCAPRKCQPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118166003-A Genetically engineered bacteria for producing staurosporine and application thereof 上海医药工业研究院有限公司 2024-06-11 — — CN claimed
CN-112980864-B Recombinant escherichia coli for synthesizing anticancer drug intermediate, and construction method and application thereof 百缮药业(苏州)有限公司 2024-04-26 — — CN claimed
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION 2023-09-14 — — US claimed
CN-113025549-B Biological glycosyl synthesis system of staurosporine framework compound and synthesis method thereof 百缮药业(苏州)有限公司 2023-06-02 — — CN claimed
WO-2023039578-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION (US) 2023-03-16 — — WO claimed
CN-115678937-A Biosynthesis method and application of K252c derivative 百缮药业(苏州)有限公司 2023-02-03 — — CN claimed
US-20250270746-A1 STABILIZED FABRICS OWENS CORNING INTELLECTUAL CAPITAL, LLC 2025-08-28 — — US disclosed
US-20250263873-A1 HYBRID FABRIC OWENS CORNING INTELLECTUAL CAPITAL, LLC 2025-08-21 — — US disclosed
EP-4519080-A1 STABILIZED FABRICS Owens-Corning Intellectual Capital, LLC (US) 2025-03-12 — — EP disclosed
EP-4519483-A1 HYBRID FABRIC Owens-Corning Intellectual Capital, LLC (US) 2025-03-12 — — EP disclosed
US-12145968-B2 Recombinant HIV-1 envelope proteins and their use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-11-19 — — US disclosed
US-20240366627-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2024-11-07 — — US disclosed
CN-118166003-A Genetically engineered bacteria for producing staurosporine and application thereof 上海医药工业研究院有限公司 2024-06-11 — — CN disclosed
CN-115678937-A Biosynthesis method and application of K252c derivative 百缮药业(苏州)有限公司 2023-02-03 — — CN disclosed
CN-115678937-A Biosynthesis method and application of K252c derivative 百缮药业(苏州)有限公司 2023-02-03 — — CN disclosed
CN-115678937-A Biosynthesis method and application of K252c derivative 百缮药业(苏州)有限公司 2023-02-03 — — CN disclosed
US-11459360-B2 Recombinant HIV-1 envelope proteins and their use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-10-04 — — US disclosed
US-20220291237-A1 Gene Expression Inflammatory Age and Its Uses Edifice Health, Inc. (US) 2022-09-15 — — US disclosed
US-11319320-B2 PIM kinase inhibitor compositions, methods, and uses thereof SNAP BIO, INC. (US) 2022-05-03 — — US disclosed
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2022-02-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 MAP3K11 1431/4885MAP3K9 1685/4885PRKCA 797/4885
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER TP53, CD4, MCL1 MAP3K11 3749/4885MAP3K9 4080/4885PRKCA 1356/4885
US-20240366627-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 MAP3K11 1431/4885MAP3K9 1685/4885PRKCA 797/4885
US-11319320-B2 PIM kinase inhibitor compositions, methods, and uses thereof PIM1, PIM2, PIM3 MAP3K11 30/4885MAP3K9 20/4885PRKCA 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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