Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 15/20 | 0.79 |
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767141 | 0.88 | ERN1 (1.00) | ERN1ESR1ESR2 | |
| SCHEMBL3268890 | 0.80 | ERN1 (0.52) | ERN1TNKS2 | |
| SCHEMBL18717073 | 0.79 | ERN1 (0.59) | ERN1ESR1ESR2TNKS2 | |
| SCHEMBL812303 | 0.76 | LMNA (0.53) | ERN1 | |
| SCHEMBL13063519 | 0.75 | ERN1 (0.74) | ERN1 | |
| SCHEMBL12675819 | 0.75 | ERN1 (0.48) | ERN1 | |
| SCHEMBL3268752 | 0.73 | ERN1 (0.46) | ERN1 | |
| SCHEMBL12377626 | 0.73 | NISCH (0.52) | ERN1TNKS2 | |
| SCHEMBL12675316 | 0.72 | ERN1 (0.56) | ERN1 | |
| SCHEMBL3267728 | 0.71 | ERN1 (0.43) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532643-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2520561-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2008154484-A1 | IRE-1A INHIBITORS | MANNKIND CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |