Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13640965 | 1.00 | CHRNA7 (0.41) | CHRNA7AKR1B1IDO1TDO2AKR1B10 | |
| SCHEMBL13640759 | 0.86 | IDO1 (0.40) | IDO1TDO2S1PR1S1PR3S1PR5 | |
| SCHEMBL12086314 | 0.83 | IDO1 (0.37) | CHRNA7AKR1B1IDO1TDO2OPRM1 | |
| SCHEMBL13640882 | 0.83 | CHRNA7 (0.41) | CHRNA7AKR1B1HTR2AHTR2COPRM1 | |
| SCHEMBL12084199 | 0.78 | OPRM1 (0.41) | CHRNA7AKR1B1HTR2ASLC6A4OPRM1 | |
| SCHEMBL8062832 | 0.77 | AKR1B1 (0.48) | AKR1B1AKR1B10MAPTAKR1A1HTR2A | |
| SCHEMBL13641059 | 0.77 | OPRM1 (0.43) | HTR2AHTR2CSLC6A4OPRM1OPRK1 | |
| SCHEMBL13640839 | 0.76 | MAP3K14 (0.38) | IDO1TDO2MAPT | |
| SCHEMBL30974103 | 0.75 | AKR1B1 (0.45) | CHRNA7AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL13640995 | 0.75 | CHRNA7 (0.41) | CHRNA7AKR1B1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497295-B2 | Spiroindoline modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120283243-A1 | Spiroindoline Modulators of Muscarinic Receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283243-A1 | Spiroindoline Modulators of Muscarinic Receptors | CHRM3, CHRM2, CHRM5 | CHRNA7 23/4885AKR1B1 500/4885IDO1 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.