Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13640730 | 0.84 | OPRM1 (0.43) | OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL13641007 | 0.84 | OPRM1 (0.43) | OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL13640927 | 0.83 | TNKS (0.37) | TNKSTNKS2OPRM1OPRL1OPRK1 | |
| SCHEMBL13641059 | 0.83 | OPRM1 (0.43) | TNKSTNKS2OPRM1OPRL1OPRK1 | |
| SCHEMBL16997309 | 0.82 | CYP2D6 (0.46) | TNKSTNKS2OPRM1OPRL1OPRK1 | |
| SCHEMBL18923751 | 0.77 | TNKS (0.41) | TNKSTNKS2OPRM1OPRL1OPRK1 | |
| SCHEMBL13640931 | 0.76 | OPRM1 (0.59) | TNKSTNKS2OPRM1OPRL1OPRK1 | |
| SCHEMBL12084593 | 0.76 | TNKS (0.44) | TNKSTNKS2OPRM1OPRL1OPRK1 | |
| SCHEMBL13644096 | 0.75 | TNKS (0.44) | TNKSTNKS2OPRM1OPRL1OPRK1 | |
| SCHEMBL1670650 | 0.74 | TNKS (0.46) | TNKSTNKS2OPRM1OPRL1AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497295-B2 | Spiroindoline modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120283243-A1 | Spiroindoline Modulators of Muscarinic Receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283243-A1 | Spiroindoline Modulators of Muscarinic Receptors | CHRM3, CHRM2, CHRM5 | TNKS 3506/4885TNKS2 3489/4885OPRM1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.