SCHEMBL13645579

SCHEMBL13645579

CC(C[Si](C)(C)C)c1ccccc1NC(=O)c1sccc1I

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.39
PKM P14618 1/20 0.37
EDNRA P25101 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.36
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.36
PRNP P04156 1/20 0.36
PPARG P37231 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
NCOR2 Q9Y618 1/20 0.36
MAPK1 P28482 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
EDNRB P24530 2/20 0.35
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 1/20 0.35
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13292781 0.83 MAPT (0.39) MAPTPKML3MBTL1LMNAHTT
SCHEMBL13645577 0.80 MEN1 (0.47) MAPTPKML3MBTL1LMNAHTT
SCHEMBL13645621 0.77 MAPT (0.45) MAPTPKMLMNAHTTMAPK1
SCHEMBL13645578 0.76 ALDH1A1 (0.44) MAPTL3MBTL1PRNPPPARGNPSR1
SCHEMBL13292661 0.75 MAPK1 (0.47) MAPTPKML3MBTL1LMNAHTT
SCHEMBL13645670 0.74 SMN1; SMN2 (0.48) L3MBTL1LMNATDP1KMT2AHPGD
SCHEMBL2906958 0.74 CYP1A2 (0.56) TDP1HPGDSMN1; SMN2
SCHEMBL13645750 0.73 ATM (0.46) MAPTPKML3MBTL1LMNAHTT
SCHEMBL13295584 0.71 HPGD (0.48) MAPTPKMPPARGNCOR2KMT2A
SCHEMBL13645646 0.71 SMN1; SMN2 (0.48) MAPTLMNAHTTRXFP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7598389-B2 Silylated carboxamides BAYER CROPSCIENCE AG (DE) 2009-10-06 US disclosed
US-20070191454-A1 Silylated carboxamides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191454-A1 Silylated carboxamides MRPL21, MRPS22, MRPS34 MAPT 3363/4885PKM 1861/4885EDNRA 2401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.