Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.51 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.51 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366251 | 0.90 | DRD4 (0.63) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1367196 | 0.89 | DRD4 (0.67) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1366874 | 0.89 | DRD4 (0.62) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1366632 | 0.88 | DRD4 (0.61) | DRD4NPC1SIGMAR1PRKAA2PRKAB2 | |
| SCHEMBL1364502 | 0.88 | DRD4 (0.61) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1364455 | 0.86 | DRD4 (0.59) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1366634 | 0.86 | DRD4 (0.62) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1366591 | 0.86 | DRD4 (0.59) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1367324 | 0.86 | DRD4 (0.59) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1365616 | 0.85 | DRD4 (0.58) | DRD4SIGMAR1PRKAA2PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067589-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | BLAKE TANISHA D | 2009-11-12 | — | — | US | disclosed |
| US-7582643-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2009-09-01 | — | — | US | disclosed |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | BLAKE TANISHA D | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | CYP11B2, CYP11B1, LTC4S | DRD4 4232/4885NPC1 168/4885SIGMAR1 2465/4885 |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | CYP11B2, CYP11B1, LTC4S | DRD4 4232/4885NPC1 168/4885SIGMAR1 2465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.