Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011796 | 0.86 | ALDH1A1 (0.44) | ALDH1A1KDM4ETPMTGAATAS1R3 | |
| SCHEMBL14041669 | 0.84 | ACHE (0.40) | ALDH1A1KDM4ETAS1R3TAS1R1MAPT | |
| SCHEMBL13083355 | 0.79 | ACHE (0.37) | ALDH1A1MAPTACHETDP1 | |
| SCHEMBL13256220 | 0.77 | ACHE (0.46) | ALDH1A1KDM4ETPMTGAATAS1R3 | |
| SCHEMBL10510118 | 0.77 | MAPT (0.50) | ALDH1A1KDM4EMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL15998073 | 0.74 | TPMT (0.35) | ALDH1A1TPMTACHE | |
| SCHEMBL2103590 | 0.74 | CYP3A4 (0.45) | ALDH1A1KDM4ETPMTGAATAS1R3 | |
| SCHEMBL931631 | 0.74 | POLB (0.44) | ALDH1A1KDM4ETPMTGAATAS1R3 | |
| SCHEMBL12401752 | 0.72 | POLB (0.40) | ALDH1A1KDM4ETPMTGAATAS1R3 | |
| SCHEMBL17084605 | 0.71 | ALDH1A1 (0.33) | ALDH1A1KDM4ETPMTGAATAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009131952-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING THIAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | disclosed |