Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 4/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16602097 | 1.00 | NPC1 (0.56) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8310016 | 1.00 | NPC1 (0.56) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL30140874 | 0.98 | NPC1 (0.55) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL25387995 | 0.86 | ALDH1A1 (0.57) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15524362 | 0.86 | ALDH1A1 (0.57) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14511443 | 0.85 | KMT2A (0.53) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14511442 | 0.85 | KMT2A (0.53) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6984561 | 0.83 | ALDH1A1 (0.54) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL29111826 | 0.83 | ALDH1A1 (0.52) | NPC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL28538251 | 0.82 | ALDH1A1 (0.60) | NPC1ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109942499-B | Quinazoline derivative and preparation method and application thereof | 湖南中医药大学 | 2022-03-22 | — | — | CN | disclosed |
| CN-109942499-A | Quinazoline derivant and its preparation method and application | 湖南中医药大学 | 2019-06-28 | — | — | CN | disclosed |
| US-7598244-B2 | [1,2,4]triazolo[1,5,a]pyrimidin-2-ylurea derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2009-10-06 | — | — | US | disclosed |
| US-20070010515-A1 | [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2007-01-11 | — | — | US | disclosed |
| US-20070010515-A1 | [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010515-A1 | [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof | HLA-C, TPMT, TAP1 | NPC1 1668/4885ALDH1A1 208/4885MEN1 728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.