Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 11/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008982 | 0.81 | DRD3 (0.60) | LTA4HKCNH2KCNA5DRD3HRH2 | |
| SCHEMBL1008080 | 0.73 | LTA4H (0.57) | LTA4HKCNH2 | |
| SCHEMBL1061860 | 0.70 | LTA4H (0.58) | LTA4HKCNH2HRH2HRH1 | |
| SCHEMBL1008214 | 0.69 | LTA4H (0.52) | LTA4HKCNH2 | |
| SCHEMBL2047433 | 0.68 | LTA4H (0.55) | LTA4HKCNH2 | |
| SCHEMBL12356761 | 0.68 | LTA4H (0.63) | LTA4HKCNH2DRD3DRD2 | |
| SCHEMBL1008190 | 0.67 | LTA4H (0.71) | LTA4HKCNH2 | |
| SCHEMBL1007996 | 0.66 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL1008432 | 0.66 | LTA4H (0.58) | LTA4HKCNH2 | |
| SCHEMBL1007807 | 0.66 | LTA4H (0.74) | LTA4HKCNH2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009126806-A2 | THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-15 | — | — | WO | disclosed |