Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.61 |
| ▸ | CDC42 | P60953 | 3/20 | 0.61 |
| ▸ | RAC1 | P63000 | 3/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.61 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CA4 | P22748 | 5/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12286244 | 0.80 | PTGS2 (0.79) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL2760404 | 0.79 | PTGS2 (0.69) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL10925467 | 0.79 | PTGS2 (0.61) | PTGS2CDC42RAC1PTGS1PAK1 | |
| Ketorolac SCHEMBL2221913 | 0.78 | PTGS2 (0.92) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL13653087 | 0.78 | PTGS2 (0.48) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL25004971 | 0.78 | PTGS2 (0.68) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL29449412 | 0.77 | PTGS2 (0.71) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL10024799 | 0.77 | PTGS2 (0.71) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL24807886 | 0.77 | PTGS2 (0.75) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL18096529 | 0.77 | PTGS2 (0.66) | PTGS2CDC42RAC1PTGS1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | CANNIZZARO CARINA | 2009-10-01 | — | — | US | disclosed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | PHOSPHO1, TNF, PTGES | PTGS2 13/4885CDC42 4210/4885RAC1 4212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.