Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987835 | 0.89 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1043108 | 0.88 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CDPIK3CGNOTUM | |
| SCHEMBL1039514 | 0.86 | PIK3CA (0.49) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1037816 | 0.83 | PIK3CA (0.49) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL13655399 | 0.79 | PIK3CA (0.82) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL12535273 | 0.78 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CDPIK3CGNOTUM | |
| SCHEMBL13655337 | 0.78 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL14938409 | 0.76 | PIK3CA (0.59) | PIK3CAPIK3CBPIK3CDPIK3CGNOTUM | |
| SCHEMBL1041502 | 0.76 | PIK3CA (0.59) | PIK3CAPIK3CBPIK3CDPIK3CGNOTUM | |
| SCHEMBL1040482 | 0.74 | PIK3CA (0.63) | PIK3CAPIK3CBPIK3CDPIK3CGNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8784774-B2 | Labeled molecular imaging agents and methods of use | GENERAL ELECTRIC COMPANY (US) | 2014-07-22 | — | — | US | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |