Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12665785 | 1.00 | KDM4E (0.42) | KDM4EHRH3HRH4ALPGMAOB | |
| SCHEMBL10159852 | 0.90 | KDM4E (0.34) | KDM4EHRH3HRH4ALPG | |
| SCHEMBL20445035 | 0.85 | HRH3 (0.35) | KDM4EHRH3HRH4ALPGMAOB | |
| SCHEMBL22307606 | 0.79 | GBA1 (0.33) | — | |
| SCHEMBL24997016 | 0.77 | — | — | |
| SCHEMBL15781118 | 0.77 | — | — | |
| SCHEMBL13472115 | 0.76 | HRH3 (0.40) | KDM4EHRH3HRH4ALPGMAOB | |
| SCHEMBL12025014 | 0.76 | ACHE (0.38) | KDM4EHRH3MAOBALDH1A1 | |
| SCHEMBL15096958 | 0.76 | ACHE (0.38) | KDM4EHRH3MAOBALDH1A1 | |
| SCHEMBL10032108 | 0.76 | HRH3 (0.40) | KDM4EHRH3HRH4ALPGMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |