Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702335 | 0.91 | HCRTR1 (0.53) | MAPTTHRBHCRTR1HCRTR2PSEN1 | |
| SCHEMBL13692066 | 0.91 | MAPT (0.42) | MAPTTHRBPOLBHCRTR1HCRTR2 | |
| SCHEMBL2753547 | 0.79 | RAB9A (0.46) | — | |
| SCHEMBL4119314 | 0.79 | HCRTR1 (0.53) | MAPTTHRBPOLBHCRTR1HCRTR2 | |
| SCHEMBL2752693 | 0.79 | HCRTR1 (0.53) | MAPTTHRBPOLBHCRTR1HCRTR2 | |
| SCHEMBL13695347 | 0.79 | MAPT (0.41) | MAPTTHRBHCRTR1HCRTR2TP53 | |
| SCHEMBL2201553 | 0.78 | HCRTR1 (0.49) | MAPTTHRBHCRTR1HCRTR2PSEN1 | |
| SCHEMBL13692072 | 0.76 | PSEN1 (0.59) | MAPTTHRBHCRTR1HCRTR2PSEN1 | |
| SCHEMBL5128978 | 0.74 | HCRTR1 (0.50) | MAPTTHRBPOLBHCRTR1HCRTR2 | |
| SCHEMBL13587103 | 0.74 | HCRTR1 (0.49) | MAPTTHRBHCRTR1HCRTR2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009124734-A2 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-15 | — | — | WO | disclosed |