Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13692066 | 0.88 | MAPT (0.42) | MAPTTHRBTP53HCRTR1HCRTR2 | |
| SCHEMBL2752693 | 0.88 | HCRTR1 (0.53) | MAPTTHRBRAB9ANPC1HCRTR1 | |
| SCHEMBL13658232 | 0.79 | MAPT (0.45) | MAPTTHRBTP53HCRTR1HCRTR2 | |
| SCHEMBL2201553 | 0.78 | HCRTR1 (0.49) | MAPTTHRBHCRTR1HCRTR2MEN1 | |
| SCHEMBL702335 | 0.75 | HCRTR1 (0.53) | MAPTTHRBHCRTR1HCRTR2MEN1 | |
| SCHEMBL4119314 | 0.75 | HCRTR1 (0.53) | MAPTTHRBRAB9AHCRTR1HCRTR2 | |
| SCHEMBL5885878 | 0.73 | RAB9A (0.57) | RAB9ANCOA1NCOA3 | |
| SCHEMBL699956 | 0.73 | NPC1 (0.44) | RAB9ANPC1NCOA1NCOA3MEN1 | |
| SCHEMBL639201 | 0.71 | NPC1 (0.42) | RAB9ANPC1 | |
| SCHEMBL14033652 | 0.71 | BDKRB1 (0.55) | RAB9ANPC1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115257-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-09-24 | — | — | WO | disclosed |