Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184060 | 0.86 | HSP90AA1 (0.44) | HSP90AA1SIRT2SIRT3SIRT1 | |
| SCHEMBL13658320 | 0.78 | HSP90AA1 (0.49) | HSP90AA1 | |
| SCHEMBL2181784 | 0.74 | HSP90AA1 (0.46) | HSP90AA1 | |
| Carbamic Acid SCHEMBL3413394 | 0.73 | HSP90AA1 (0.44) | HSP90AA1 | |
| SCHEMBL13658358 | 0.73 | HSP90AA1 (0.48) | HSP90AA1 | |
| SCHEMBL2181819 | 0.73 | HSP90AA1 (0.54) | HSP90AA1 | |
| SCHEMBL3415327 | 0.70 | HSP90AA1 (0.48) | HSP90AA1 | |
| Hydrochloric Acid SCHEMBL2183077 | 0.70 | HSP90AA1 (0.47) | HSP90AA1 | |
| SCHEMBL2184471 | 0.69 | HSP90AA1 (0.61) | HSP90AA1 | |
| Carbamic Acid SCHEMBL2184190 | 0.68 | HSP90AA1 (0.46) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |