Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23942099 | 0.73 | AHR (0.41) | KMT2AAXLNUDT1ADORA2AADORA1 | |
| SCHEMBL13659491 | 0.72 | CHEK1 (0.47) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL11898184 | 0.70 | JAK2 (0.50) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL22744001 | 0.69 | PARP1 (0.37) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL23137414 | 0.69 | CHEK1 (0.49) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL4243560 | 0.69 | CHEK1 (0.41) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL14626390 | 0.69 | HPGD (0.36) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL13659576 | 0.69 | PARP1 (0.50) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL13662688 | 0.68 | JAK2 (0.34) | JAK2RPS6KA3MELKSTK24CHEK1 | |
| SCHEMBL10525022 | 0.68 | PARP1 (0.44) | JAK2RPS6KA3MELKSTK24CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, CDKN1A | JAK2 1085/4885RPS6KA3 1455/4885MELK 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.